Upon consideration, I’ve come to the conclusion that the only Marvel super-scientist it would actually be interesting to see Shuri square off against is Dr. Doom. Consider:
Resources: Both have the ability to throw the full economic might of a small developed nation at their problems.
Materials: Shuri has a literal mountain of vibranium. Doom is a sorcerer on par with Dr. Strange and can bullshit up whatever impossible substances he needs.
Backup: An elite corps of the world’s most highly trained warriors in Shuri’s corner; endless hordes of disposable robots in Doom’s.
Philosophy of what technology is for: Diametrically opposed.
Style: Bellowing, monologuing cartoon character who refers to himself exclusively in the third person versus Millennial grasp of irony.